Erythrocyte coproporphyrin and protoporphyrin in ethanol-induced sideroblastic erthropoiesis.
نویسندگان
چکیده
منابع مشابه
Lead toxicity and heme biosynthesis.
Lead intoxication results in a disturbance of heme biosynthesis, its degree depending on the severity and duration of exposure to lead. A mild secondary, sideroblastic anemia is common; basophilic stippling may occur, especially in severe lead poisoning. Increased excretion in the urine of delta-aminolevulinic acid and coproporphyrin III may occur; porphobilinogen excretion is not usually incre...
متن کاملEFFECT OF CHRONIC LEAD POISONING ON ERYTHROCYTE PROTOPORPHYRIN IN RATS
Research has shown that exposure to lead may have adverse effects at different blood lead concentrations. Lead inhibits at least two enzymes that are essential for the formation of heme, and because of the interaction of lead with these enzymes, no iron is inserted into protoporphyrin. Therefore the concentration of protoporphyrin increases in erythrocytes. The concentration of lead was mea...
متن کاملSideroblastic anemia with markedly increased free erythrocyte protoporphyrin without dermal photosensitivity.
A patient with idiopathic sideroblastic anemia and atypical clinical and biochemical findings is described. He had a greatly increased erythrocyte and plasma protoporphyrin, but normal urine and fecal porphyrins. The erythrocyte protoporphyrin had a fluorescence spectrum typical of free protoporphyrin, but caused no photosensitivity. Bone marrow metal chelatase activity was normal. There were n...
متن کاملAbnormal Iron Incorporation, Survival, Protoporphyrin Content and Fluorescence of One Red Cell Population in Preleukemic Sideroblastic Anemia
The dimorphic blood picture in sideroblastic anemia suggests the coexistence of at least two types of erythrocyte, the populations with the smaller RBCs being responsible for the crucial abnormality, namely the impairment of iron incorporation into protoporphyrin. In a patient with sideroblastic anemia who subsequently developed acute myelocytic leukemia, we found a light and a heavy cell popul...
متن کاملAbnormal iron incorporatin, survival protoporphyrin content and fluorescence of one red cell population in preleukemic sideroblastic anemia.
The dimorphic blood picture in sideroblastic anemia suggests the coexistence of at least two types of erythrocyte, the populations with the smaller RBCs being responsible for the crucial abnormality, namely the impairment of iron incorporation into protoporphyrin. In a patient with sideroblastic anemia who subsequently developed acute myelocytic leukemia, we found a light and a heavy cell popul...
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عنوان ژورنال:
- Blood
دوره 43 2 شماره
صفحات -
تاریخ انتشار 1974